Sentence examples for translation dysfunction from inspiring English sources

Therefore, we have used RBS as a disease model to address mTOR-associated transcription and translation dysfunction.

Our findings may help elucidate how the loss of FMRP leads to aberrant mRNA translation and synaptic dysfunction present in Fragile X syndrome.

Recent studies indicate that oxidative damage to RNA results in dysfunction of translation and eventual pathogenesis.

Thus, the severe decrease in the GAPDH pool levels of the young in the presence of GAPDH transcript suggests that dysfunction of translation may also be involved in the young following I/R [ 36, 37].

The rate of aging, however, is influenced by diverse factors, including protein translation, protein quality control, mitochondrial dysfunction, and metabolism (Kennedy and Kaeberlein, 2009; Webb and Brunet, 2014; Lagouge and Larsson, 2013; Barzilai et al., 2012).

Similarly, it remains unclear how C9ORF72 repeat expansions trigger ALS pathology, although haploinsufficiency due to impaired transcription/splicing, leading to reduced C9ORF72 protein expression (up to 50%) (8), RNA dysfunction, and unconventional translation of the repeat to generate insoluble polypeptides, are possible mechanisms (9, 10).

The induction of apoptosis by D-GalN was associated with ROS production, mitochondrial dysfunction and post-translation (S-nitrosylation and Tyrosine nitration) modifications of proteins involved in unfolded protein response, enzymatic antioxidants, cell metabolism and death in cultured human hepatocytes.

The discrepancy between Itgam mRNA expression and cell surface protein levels of CD11b in db-derived macrophages might be due to dysfunctions in protein translation, misfolding and subsequent degradation, or in localisation in db-derived cells, as has been seen for other proteins (Hamilton et al., 2013; Yu et al., 2007).

To date there is no example of 'bench to bed' knowledge translation of drugs to benefit sexual dysfunction.

The second line of Mitchell's translation opens up the nature of the dysfunction.

Nonetheless, prolonged stress may lead to reduction in the translation of cellular protein and, consequently, neural dysfunction and neurodegenerative disease.