Sentence examples for translation disruption from inspiring English sources

As with any complex phenotypic assay, cell migration during wound healing can be inhibited by effects on global cellular processes – e.g. inhibition of protein translation, disruption of metabolism, disruption of ion homeostasis, etc. – and validation of the specificity of new perturbations is required.

Because of its key function as the primary restraint against anterior tibial translation, ACL disruption inevitably causes alterations in knee kinematics which are most likely to result in secondary degenerative changes and long-term functional impairment [2, 3].

The maintenance of the MSC is essential for mRNA translation, and disruption of the MSC leads to a reduction in protein levels of member AARSs and a concomitant drop in AARS activity, leading to reduced mRNA translation rates [ 69].

A prominent example of this is the conserved nutrient-sensing protein kinase TOR (target of rapamycin), which positively regulates mRNA translation; its disruption during C. elegans development causes growth arrest or lethality, but its inhibition in adults prolongs lifespan (Hansen et al., 2007).

Such functions include the inhibition of host mRNA translation by disruption of the RNA splicing machinery and promoting nuclear export of viral mRNAs by ICP27 (reviewed in Smith et al., 2005) and evasion of CD8+ T cell recognition via ICP47-mediated TAP inhibition (Früh et al., 1995; Hill et al., 1995).

Like other piRNA pathway mutations, armi oocytes show phenotypes associated with the response to DNA damage caused by excessive transposon expression, including failure to restrict anterior grk mRNA localization to a dorsal corner due to a misorganized MT cytoskeleton, silencing of Grk translation, and disruption of the karyosome (not shown; Klattenhoff et al. 2007; Pane et al. 2007).

The paucity of chimeric TE insertions in exons relative to introns demonstrates that the deleterious effects of chimeric TE insertions must exceed the cost of simply being transcribed, and probably results from improper translation or disruption of other functions of the mRNA such as localization or stability.

Our results indicate that, regardless of the genomic context, the histidine moiety does not become incorporated in proteins via ribosomal translation, and that disruption of the TLS in either viral RNA does not perturb the viral translation patterns.

That inhibition of a maternal process such as mitochondrial translation leads to disruption of zygote cleavage, and haploid parthenotes show similar distribution pattern and dynamics of the mtrRNAs to the zygote further support the possibility of pre-patterning of the mouse oocytes.

Evidence demonstrating alterations to chromatin structure, bi-directional transcription and non-ATG-initiated translation suggests that disruption of multiple molecular pathways may contribute to the DM phenotype (21, 22).

PDCD4 binding to eIF4A is required for its ability to inhibit translation and transformation as disruption of eIF4A binding to PDCD4 abolishes its effect on both [ 26].