The classical description of RelE as a toxin implies that it is a nonspecific inhibitor of translation, most compatible with a role in cell growth stasis or even cell death.
If the presence of a hydrophobic sequence in the ribosomal tunnel would preferentially extend those stages of the translation cycle compatible with SRP binding, this could provide a mechanism for tunnel-initiated SRP recruitment.
While a certain set of site symmetries constitutes a point symmetry group in the Euclidian plane and requires a compatible translation symmetry type, a certain translation symmetry type enables a few sets of site symmetries in 2D-periodic images.
The fact that downregulation of actin (which is necessary for vesicular trafficking of VSG) also triggers a severe translation arrest is compatible with this possibility.
In such cases of "radical translation", different translators, working independently on Jungle, could thus produce quite divergent manuals of translation, each compatible with the totality of the native-speakers' verbal behaviour, but incompatible with one another.
Pairwise alignments between sequences of the two libraries in translated form were then obtained from BLASTP of the obtained fiNOG-compatible translations.
(ii) mRNA for N-Bak was remarkably stable in the neurons that is not compatible with translation-associated rapid degradation.
This is again inconsistent with the translation initiation hypothesis, but somewhat compatible with the amino acid constraint hypothesis.
The major roadblock to the ribosomal synthesis of highly modified drug-like peptides is the limited number of unnatural building blocks known to be compatible with the translation apparatus.
In addition, mRNA display has substantial advantages over phage display for peptide selection, in which (i) the library size of the former is much larger than that of the latter, and (ii) cell-free translation of the former is compatible with the incorporation of unnatural amino acids [35] [38].
AaRSs discriminate against near- and non-cognate tRNAs at levels compatible with typical translation error rates (∼10−4) due to the structural complexity and diversity observed between tRNA isoacceptors.
