For example, it is counterproductive to transcribe a gene if the translation apparatus is not capable of translating it.
In agreement with the latter finding, the synthesis of many mammalian proteins associated with the translation apparatus is regulated at the translational level [ 25] to allow for fast responses to changes in physiological conditions.
TSA1 functions as antioxidant on actively translating ribosomes and thereby maintains the integrity of the translation apparatus.
For this study, we sought to identify the translational defects in two new types of mutants that affect the translation apparatus.
In addition, the yeast lysates mediated translational initiation through several viral internal ribosome entry sites, demonstrating that the yeast translation apparatus can perform internal initiation.
The French translation apparatus at international organisations is well oiled.
During cellular translation of messenger RNAs by ribosomes, the translation apparatus sometimes pauses or stalls at the elongation and termination steps1,2,3,4,5,6.
Viruses have evolved a remarkable variety of strategies to modulate the host cell translation apparatus with the aim of optimizing viral mRNA translation and replication.
As invading viruses do not harbor functional ribosomes in their virions, successful amplification of the viral genomes requires that viral mRNAs compete with cellular mRNAs for the host cell translation apparatus.
A likely consequence of this role of 2A is the efficient translation of viral mRNAs early in the infectious cycle, when host cell mRNAs can still compete with viral mRNAs for the host cell translation apparatus.
Ribosomal profile analyses show that the heterodimer preferentially associates with the translation apparatus in neuronal cells and arrests translation at the HRV2 IRES, preventing PV-RIPO RNA assembly into polysomes.
