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The effects of E2 and 4- t-OP on post-translational and/or miRNA control of nuclear receptor translation and function were not investigated in this study, and cannot therefore be discounted.
While bioinformatics can be useful in unearthing smORF candidates, ultimately experimental evidence and full functional characterisation is the only way to ascertain the translation and function of each individual smORF.
We report several novel mutations within regulatory and coding regions that could affect gene transcription, translation and function.
At present various options are under consideration: (a) direct modulation of the transporter by specific inhibitors, (b) interference with the regulatory cascade of protein transcription, translation and function, and (c) encapsulation of substrates into delivery systems, which are able to by-pass p-glycoprotein.
Interestingly, increased levels of eIF-4E and eIF-2 favor LIP translation and function through associations with the uORF (Fig. 1) [ 34].
Early transcriptome studies found that key P. falciparum protein-coding genes are typically transcribed only once per blood stage, 'just-in-time' for translation and function [ 17, 18].
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In the late blastocyst stage, genes were significantly enriched in protein translation and function-associated pathways such as protein localization, transport, and phosphorylation.
Since the mTOR pathway is a critical regulator of protein translation and ribosome function, and p53 is an indicator of nucleolar stress, translational impairment may contribute to differential gene expression in RBS.
In addition, the Cdkal1 homolog Cdk5rap1 regulates mitochondrial protein translation and mitochondrial function in skeletal muscle.
Many genes implicated thus far, which are involved in chromatin remodelling, metabolism, mRNA translation and synaptic function, seem to converge in common pathways or genetic networks affecting neuronal and synaptic homeostasis16.
On the basis of the one-dimension infinite element theory, the coordinate translation and shape function of 3D point-radiate 8-node and 4-node infinite elements are derived.
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