In the subsequent part of this review, we propose that the methionine homocysteine or 1-C arbon) cycle may play an integrating role in translating the effects of oxidative stress on FA metabolism.
By translating the effects of environmental stimuli into coordinated gene expression programs for cellular adaptation, epigenomic pathways are mechanistic links between the genome and environment that are important in understanding common cardiovascular diseases.
Nevertheless, when looking specifically at the set of active gene set and stimulus pairs (n = 560), 30% were correctly predicted by at least three teams (Fig. 5A), and in contrast to phosphorylation activation, six of seven teams in SC3 were better at globally translating the effects of stimuli than gene set activity (Fig. 5B).
However, this requires large scale hydrological models to translate the effect of reservoir operation to downstream points of interest, in a quality sufficient for the iterative development of optimized operation strategies.
Kinetic reaction expressions based on the mechanistic Langmuir Hinshelwood (L H) model were derived and tested by regressing the experimental data that translated the effect of both naphthalene and hydrogen concentration at a constant temperature (523.15 and 573.15 K over the NiMo catalyst and at 373.15 K over the Ni and Ru/Al2O3 catalysts) on the initial reaction rate.
In Part v, we proposed that the 1-C cycle may translate the effect of oxidative stress on FA metabolism: indeed, psychiatric disorders and CVD are both associated with oxidative-stress-associated increases in homocysteine and reductions in folate.
To translate the effects of stress changes and their time dependency into seismicity, we have to know the real background seismicity rate r in Eq. (3).
Next, we attempted to translate the effects of TGF-β inhibition using animal models.
Drugs that inhibit the TOR pathway can serve as powerful tools to translate the effects of the TOR pathway on lifespan in simpler invertebrate model systems to more complex systems like mammals.
A major challenge in translating the positive effects of dietary restriction (DR) for the improvement of human health is the development of therapeutic mimics.
