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This method involves correcting invalid or incomplete KGML content, creating complete and valid stoichiometric reactions, translating relations to signaling models and augmenting the pathway content with various information, such as cross-references to Entrez Gene, OMIM, UniProt ChEBI, and many more.
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This is used to translate relations that describe, e.g., a phosphorylation.
An InteractionVocabulary is created for each translated relation that specifies the type of interaction as controlled vocabulary term and human-readable string.
Data extraction and synthesis was guided by the seven phases used in meta-ethnography articulated by Noblit and Hare [ 36], which include: identifying the area of interest, deciding what is relevant, reading and re-reading the studies, deciding how the chosen studies are related, translating the studies in relation to one another, synthesising translations and presenting the synthesis [ 44].
These include universal elements, such as Conversions or MolecularInteractions, which are convenient for translating generic KEGG relations that do not provide much information.
One can also go further: instead of translating the identity relation = into something more complex, we may keep the language simple and complicate the interpretation.
His exclusive dichotomy (real & causal vs. unreal & conceptual) serves not only as a tool for refusing a separate self, but also as a method of denying apparent subject/object relations or apparent substance/quality relations, and translating them into linear, causal series.
However, when thinking in term of diseases, these relations translate into "is-a-kind-of" relations, e.g. bronchial diseases are a kind of respiratory diseases.
In general, learners' ability in translating between, seeing the relations between MERs and connecting across MERs, plays an important role in deciding learning effectiveness while learning from MERs (Ainsworth 1999, 2006; Kozma and Russell 1997).
Until now, there exists no BioPAX to SBML converter that is fully capable of translating both reactions and relations.
If the diagram is drawn correctly, then there are some simple rules that can be used to translate it into relations that avoid most relational design problems.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com