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This involves analysing the existing best practice and translating clinical decisions and manual fabrication tasks into a digital workflow suitable for use by clinicians.
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PCM can only be achieved through the development of patient-oriented research, the results of which could be translated into clinical decisions that increase the effectiveness of medical care.
When this ambiguity of the results of measurements is translated into clinical decisions based on the recommendations of Fresenius Medical Care the results from the same post filter sample could vary from a maximum increase of citrate flow (by 0.3 mmol/L) to a maximum decrease of citrate flow (by 0.3 mmol/L) depending on the instrument used.
Diagnostic specificity beyond the symptom of low back pain or the presence of lumbar degeneration needs to be delineated such that outcomes data can be effectively translated into clinical decision making or evidence-based guidelines.
This response can be measured and translated into clinical decision support tools.
Most importantly, intensivists and emergency physicians should explore whether risk stratification using NGAL will translate in clinical decision-making.
Population mean change in pain intensity reported in clinical trials may be difficult to translate into clinical decision-making and patient expectations of benefit.
Therefore, some measure of expression level, or present/ absent value must be assigned to each node in a healthy state vs. a cancer state before differential topological calculations can produce meaningful biological insights that translate into clinical decision making at the treatment and progression levels.
Such differences do not necessarily translate into changes in clinical decisions: Simel and Bossuyt found only modest differences in estimates of the likelihood ratios and importantly, posterior probabilities, when univariate and bivariate methods were compared [ 42].
This situation does not directly translate into a clinical decision-making point.
Despite the remaining obstacles, we believe the stepwise introduction of mechanistic, network biology-based mathematical models will be essential for translating knowledge about molecular biology into clinical decisions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com