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It was proposed that specific mRNAs that are poorly translated when translation initiation is low or normal become highly translated upon eIF2α dephosphorylation [22].
Gcn4 is a transcriptional activator that is translated when translational activity is poor 16.
While IRES-mediated translation mechanism can explain how these viral and eukaryotic genes can be translated when cap-dependent translation machinery has been attenuated, the nature of IRESs and their molecular details are not fully understood.
These results indicate that HIV-1g mRNA can be translated when cap- and poly(A -dependent A -dependentis arrestranslationtisg the concept tharrestedlation initiation of thisupportingceeds by a non-canonical mechanism.
Together, these results suggest that IRES elements provide an alternative route by which specific mRNAs continue to be translated when the proper functioning of the cap-dependent translational machinery becomes compromised.
Then she translated when a reporter asked a question in Spanish.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com