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To translate this strategy for combined 6TG conditioning and chemoselection into a clinically feasible approach, it is necessary to develop methods for genetic modification of normal hematopoietic stem cells (HSC) to render them HPRT-deficient and thus 6TG-resistant.
Further investigations are needed to translate this strategy into humans, but it constitutes a promising therapeutic approach.
We must be able to translate this strategy into work and prosperity, a goal that can be achieved only if we manage to eliminate excess bureaucracy and create a strong business environment.
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Therefore, translating this strategy to a clinical context may have potentially important therapeutic significance.
We translated this strategy in vivo, in nude mice bearing sensitive and gefitinib-resistant GEO and GEO-GR colon tumours, respectively.
We first designed the search strategy in PubMed (Additional file 1), and then translated this search strategy into the other electronic databases using the appropriate controlled vocabulary as applicable and free-text terms.
Consequently, the challenge is to translate this information into strategies that prevent CRC.
Because these experiments were performed in model systems that mimic many essential elements of human breast cancer, the results strengthen the rationale for translating this prevention strategy to humans at high risk for developing breast cancer.
Consequently, we decided to investigate Taspase1 at the molecular level, aiming to understand the functional relationship between Taspase1 and AF4 MLL, and to translate this knowledge into novel strategies aiming to block the oncogenic functions deriving from AF4 MLL.
To translate this finding into a therapeutic strategy we designed new hydrogen peroxide-activated agents with two key molecular pharmacophores.
We know there are similar disparities between elite institutions like the Mayo Clinic in Minnesota and Mt. Sinai Hospital in New York City, but lack a strategy to translate this knowledge into policy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com