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Furthermore, in AIY neurons, MGL-1 appears to use neuropeptide signaling, rather than glutamate, to translate starvation stimuli into delayed oogenesis and embryogenesis.
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Future studies might examine how short-term CR or starvation exposures at different maternal ages translate into effects on offspring aging, to determine the timing and trigger for the maternal effect.
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Under repressing conditions (amino acid replete), nearly 80% of ribosomes translate uORF4 and abandon the mRNA after scanning just 32 nucleotides, whereas only about 20% of the ribosomes do so under derepressing conditions (amino acid starvation).
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The first of four uORFs within the GCN4 5′ leader is efficiently translated under both good nutritional and starvation conditions and establishes a "reinitiation mode of translation" 14 for all downstream initiation codons 12, 13.
Although it is currently unknown how serum starvation is sensed and translated to signal transduction in 5637 cells (see below), our present study demonstrates for the first time the importance of MDs in this kind of signal transduction.
In the U. maydis experiments, the period of carbon starvation was much longer and translation was not assessed; however, the existence of ribosomal protein transcripts suggests measuring translation before during and after carbon starvation may show that mRNAs were stabilized and not translated, a situation similar to the teliospore.
The D. melanogaster to transcript has been shown to be induced by starvation and been proposed to participate in a novel circadian output pathway that translates temporal and food status-related information into feeding-relevant metabolism and activity [ 9, 10].
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