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Similarly, the context of an ORF or uORF stop codon can exert general effects on translation by modulating the ability of the ribosome to reinitiate after termination and translate downstream ORFs [ 26].
Non-locality occurs due to mean tangential flow along the flame brush, which causes flame wrinkles to translate downstream.
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These 48S complexes reinitiate (i.e. recognise and subsequently translate) at downstream uORFs 3 and 4, which have 3' sequence contexts that promote ribosome release.
However, the processes by which forces are transduced to biochemical signals and subsequently translated into downstream effects are poorly understood.
Of transcriptional regulators predicted, the stress-responsive transcription factors NRF2 and HSF1 are of particular interest for understanding how oxidative signaling is translated into downstream effects.
Moreover, we provide solid evidence that oxidative stress is translated into downstream effects through stress-responsive transcription factors as highlighted by NRF2 and HSF1.
In −1 frameshifting, only a defined percentage of the translating ribosomes shifts to the −1 reading frame and translates the downstream gene.
Providing such interventions early could translate into significant downstream public health savings, in terms of reduced hospitalizations, falls, or transition to residential care.
Because of this approach, and due to the fact that pot-grown biomass yields did not vary with RW induction in any of the genotypes, any improvements in sugar release yields should translate to real downstream yield benefits.
We then investigated what downstream pathways translate palmitate- and oleate-induced elevated ROS levels into dysfunction of pancreatic β-cells.
As we have tried to emphasize in this work, a place cell response does not necessarily translate into information communicated downstream.
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