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Concentrated research into bioreactor-based differentiation strategies has stemmed from the need to translate differentiation from a lab-scale area of research into processes capable of producing industrially relevant cell numbers in a reproducible manner.
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How to translate the differentiation into changes of biological activities is another key problem in the functional genomics of ageing.
To translate the differentiation into changes of biological activities, we make statistical inference by integrating the expression profiles with biological gene subsets defined by Gene Ontology, KEGG pathways, and cellular localization of proteins.
It is becoming increasingly evident that the regulation of translation of key mRNA species governs differentiation; for example, a group of mRNAs (comprising 2% of total transcripts) was shown to be specifically translated during differentiation of embryonic stem cells, including Wnt1 [27].
Increased rates of BrdU incorporation in the GFP− myocyte fraction would translate to myogenic differentiation of progenitors during the course of BrdU pulsing.
This research was particularly relevant because it considered how species' differentiation across geographic space became translated into evolutionary differentiation through time.
This bottleneck could translate into a strong differentiation by founder effects and drift.
How the different complexes are stabilized, how this translates into cell differentiation and how RUNX1 levels come into play will be a fascinating topic for further investigations.
The development of a universal cardiac differentiation protocol that can translate across multiple pluripotent stem cell lines allows immediate application to genetically diverse hiPSC lines created from patients with cardiac related diseases (e.g. long QT syndrome [50], [51]).
Thus, variations in occupational orders translate into variations in social stratification and differentiation in lifestyles and life chances.
These factors, together with other molecules in cluster 272, may integrate and translate external stimuli into a signal for sexual differentiation.
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