Effect models translate a concentration or body burden in a biological compartment to an effect on either an organism, a population, a community, an ecosystem, a landscape, or the entire ecosphere.
In some experiments, known concentrations of polyclonal IgG where the source was a pharmaceutical preparation intended for intravenous immunoglobulin therapy (Privigen; CSL Behring, Stockholm, Sweden) were serially diluted, coated on ELISA plates and used as a standard curve to translate the concentration of anti-CII from arbitrary units per milliliter to micrograms of anti-CII IgG per milliliter.
In order to translate activity concentrations to absorbed doses, information about radionuclide biokinetics, absorbed fractions and organ masses are needed [48].
The Interaction-Identifier method follows recent efforts [ 12, 25, 26] to translate TF concentrations into the equilibrium probability of RNAP binding using thermodynamic models.
This is an expected consequence of the nominal aqueous phase concentrations, which translate into significant concentrations in the bilayer due to the compounds high partition coefficients into the membrane.
Data detected by PET scanners is translated into concentration of radiotracer by using image reconstruction methods.
Hill's slope (N) is the primary PD parameter that measures the sensitivity with which a particular system translates the concentration of a drug into an effect; therefore, the highly specific mechanism of action of gentamicin usually gives N near to 1, just as we observed with the innovator (N = 1.20±0.2) or the therapeutically equivalent generics (N = 1.30±0.19; P = 0.1846 by CFA).
The normalised AQUA score was translated into concentration units of EGFR (nanograms of EGFR per microgram of total protein), using the standard curve derived from the previous study (Dimou et al, 2011).
In addition, high renal drug concentrations may not translate into high concentrations in the target cell and, in pathological conditions such as abnormal glomerular filtration, tubular secretion or proteinuria, the distribution of drugs to the kidney may be affected.
PK considerations should then translate the MABEL concentration to the associated predicted concentrations in the plasma compartment.
