The fact that p53 fundamentally changes its dynamic mode, that is, switching from pulsing at low damage to monotonic increase at high damage, poses important new questions regarding the transitional behavior and regulation of p53 pathway dynamics.
Our findings not only provide important new insights into understanding the differential DNA-damage response mediated by p53, but also produce quantitative new data for exploring the transitional behavior and regulation of p53 pathway dynamics for cell-fate control.
The U.S. media landscape, on the other hand, is almost exclusively dominated by privately owned corporations, which begs the question whether the U.S. could serve as a model of media regulation for transitional states.
The new rule established a transitional period of 5 years to comply with the regulation.
As modulators of transitional events, miRNAs participate in the regulation of regeneration process through temporal clearance of unneeded transcripts.
In sum, the clustered transcriptional profiles indicated a three-stage temporal dynamic of genome-wide transcriptional regulation: early (<12 hr), transitional (12~24 hr) and late (>24 hr) stages.
[N] More specifically, respondents from all three groups expressed concerns with the actions of the Transitional Councils responsible for drafting their respective new regulations: After reviewing the Draft regulation put out by the Transitional council, my support for regulation diminished almost immediately.
We provide a synthetic framework centered on the idea that different evolutionary processes dominate during different transitional stages, beginning with changes in gene regulation and culminating in novel genes later on.
[N] After reviewing the Draft regulation put out by the Transitional council, my support for regulation diminished almost immediately.
With the phaseout, homeowners should initially move to hybrid halogen bulbs, a transitional product that only barely meets the new regulations, and compact fluorescents.
