Whether or not the endocytosis occurred via transition through a detergent-insoluble stage as suggested by Goldsmith et al. [35], in any case the final result is an almost complete GH-induced degradation of GHR after 60 min. The results support the hypothesis that Jak2 kinase activity is required for GHR endocytosis.
It is currently unclear whether the RANK-responsive TECs contained within the CD205− fraction represent cells that have already transitioned through a CD205+ stage and subsequently lost CD205 expression by E12.
Since Type 1 progenitors are thought to differentiate into mature neurons by transitioning through a neuroblast stage, we next examined DCX immunostaining in the Cux2-ires-Cre fate-mapped DG.
It takes years to build a successful start-up company, say the founders of Vascular Magnetics; your company probably will transition through a number of stages before a product reaches the market and benefits a patient.
Although this notion is teleologically appealing, emerging data are more consistent with a model where naïve cells directly develop into memory cells without transitioning through an effector stage.
Microelectrode array (MEA -plated neurons transition through this stage of coupled superbursting before establishing MEA -platedoneuronsnotransitionithrough
Unfortunately, neither the government, nor the civil society institutions and women's rights activists have planned for the transition through this stage to enable us to stand on our own feet afterwards.
Multistage theories of carcinogenesis predict that a person's susceptibility to benzene-induced leukemia will depend upon the age at which exposure occurs, as the probability of transition through the stage (or stages) of the disease process unaffected by benzene exposure are assumed to be age dependent (Thomas 1988).
There was, however, a significant increase in the production of BrdU/NeuN-positive cells in the CBD group (CBD vs. CTR: 297 ± 32 vs.146 ± 23; n = 5; p = 0.001; Fig. 2A, B), suggesting that in this case an accelerated transition through the DCX stage might result in more neurons, an effect absent in the case of THC.
However, it has been shown that in a stage-wise analysis, a loss of information occurring in the transition through stages can be minimized by an appropriate weighting scheme [ 9].
