Sentence examples for transition of stem from inspiring English sources

These findings contribute to the development of biomimetic materials, allowing a deeper understanding of signaling pathways that govern the transition of stem cells towards the osteoblastic lineage.

mSWI/SNF subunit exchange assists the transition of stem cells from pluripotency to a multipotent state, and further to terminal differentiation.

In self-renewing cells, CCNE is constitutively active throughout the cell cycle, which allows the transition of stem cells from M phase directly to late G1.

In this section, we envision how recent advances in epigenomics can be used to gain insight into human development and disease, and to facilitate the transition of stem cell technologies towards clinical applications.

For visualization of neuronal differentiation using molecular imaging techniques, neuron-specific promoter-driven optical reporters can be used as simple imaging system to monitor the transition of implanted stem cells into neuronal lineage in vivo.

A survey of the 66 genes included in this PE-like group reveals the presence of 5 genes involved in calcium homeostasis (calcR, ryr-3, otopetrin1, tnnc2 and cyp24a1) suggesting that calcium signalling plays an important role in the transition of pluripotent stem cells into ectodermal fates.

Genome-wide remodeling of H3-K9 methasation has been implicated in the transition of embryonic stem cells to mesenchymal-like cells and ascorbic acid (vitamin C -mediated reduC -mediated-K9 methylation-induced treduction of mesenchymal-like cells to embryonic stem cells.

Taken together, these findings demonstrate that Pou3f1 is most likely an intrinsic neural initiation factor that participates in the transition of pluripotent stem cells to NPCs by directly activating a group of key neural fate-promoting genes.

This model incorporates two features: transition of target stem cells into cancer cells via an intermediate stage in two irreversible steps and growth and differentiation of normal target and intermediate cells.

Embryonic stem cells deplete of Dicer, an essential component of the miRNA processing machinery, fail to induce a differentiation marker upon induction of differentiation in vitro [ 6]. miRNAs are also involved in fine-tuning gene expression during the transition of neuronal stem cells to neuronal progenitors and neurons [ 7].

In contrast to the orderly transition of normal stem cells through differentiation with generation of progenitor and terminally differentiated cells, multistep carcinogenesis is likely to generate heterogeneity in cancer-initiating population, which is reflected in different cell surface markers that identify cancer stem cells in different tumor types.