Sentence examples for transition of prostate from inspiring English sources

Further, they may play an unknown function in the transition of prostate cancers from androgen dependence to independence.

Thus, understanding the molecular mechanisms of the transition of prostate cancers from androgen dependence to independence remains an important challenge.

Thus, loss of EGFR regulation and altered signalling may, in part, explain the transition of prostate tumours from androgen dependent to androgen independent.

To further assess the effects of 5-Aza-CdR on the transition of prostate cancer, we examined the free prostate-specific antigen (FPSA) concentrations, an important clinical parameter for screening and testing prostate cancer [ 20].

Indeed, an AR responsiveness persists in the androgen-dependent to -independent transition of prostate cancer [ 136] and, with its co-activator SRCAP, AR could potentially bring the over-expressed H2A.Z.1 to different promoters.

The results revealed that NF- κB/p65 nuclear translocation occurs in the transition of PIN to prostate cancer.

In the past decade, many studies were conducted to investigate the mechanism that causes the transition of hormone dependency in prostate cancer [ 3, 4], including low throughput experiments, such as Western blot, real-time PCR, and Northern blot [ 5, 6], and high-throughput studies including microarray experiments [ 7- 9].

Therefore, 10 of 13 (77%) of the GWAS genes were differentially expressed in the transition from normal prostate to prostate cancer that is higher than one can expect to detect among randomly chosen 13 genes −1.1 (χ2 = 20.9, df = 1, P<0.0001).

The parallel impact of suppressed Id1 and 3 on these two very different cell lines implies a core role for the Id proteins in regulation of G1/S transition in prostate cancer cells that is independent of known differences between the two cell lines, for example, androgen receptor status, phosphatase and tensin homolog status, p53 and Rb mutations.

AR activity has been implicated as pivotal in several phases of prostate cancer: origin, transition to androgen independent status, and progression.

We also looked specifically at the expression of integrins at the initial stage of prostate tumorigenesis – the transition from NP to PIN – using gene expression data from Tomlins et al. [ 29].