Therefore, we hypothesized that G2/M transition of progenitors is promoted during the night, which will result in the increase of M-phase cells.
These results strongly support the idea that transition of progenitors from a hypoxic niche to normal tissue oxygen contributes to cell death.
Taken together, this suggests that miR-9 is necessary for the transition of progenitors to neurons across the AP axis, and in addition it is required for the survival of progenitors in the forebrain.
If apical/basal astral microtubules are key to controlling spindle and cleavage orientation, what then is the role of the central astrals unaffected by the proliferation-to-neurogenesis transition of progenitors and that remained constant upon minimal nocodazole treatment or functional LGN ablation?
In this paper, we sought to determine whether the change in phosphorylation induced by transcriptional cofactor binding plays a positive or negative role in the ability of Gro/TLE1 to inhibit/delay the transition of cortical progenitor cells into neurons.
We previously used this approach to uncover a requirement for miR-206 and, to a lesser degree, for miR-1 activity for Pax3 downregulation in the somite myotome, which ensures the timely transition of myogenic progenitor to committed myoblast (Goljanek-Whysall et al., 2011).
Magri, L. et al. E2F1 coregulates cell cycle genes and chromatin components during the transition of oligodendrocyte progenitors from proliferation to differentiation.
Since NKX2.5 expression identifies a cardiac progenitor cell population [42], [43], regulation of this upstream portion of the sodium-calcium exchanger 1 gene may be critical to the transition of cardiac progenitors from the primitive state to the pool of amplifying myocytes.
Exploiting the accessibility of the chicken embryo for in vivo manipulations, we previously identified a crucial role for miR-206 during the transition of myogenic progenitors to committed myoblasts.
To get insights into the mechanism through which infiltrating MPs restrict EndoMT, we analyzed the expression of growth factors, cytokines, proteases and chemokines in the healing muscle from day 5, a time after which we start observing mesenchymal transition of endothelial progenitors.
The transition of a RG progenitor to an IP is associated with the downregulation of Pax6 and the upregulation of Tbr2 (Englund et al., 2005), which is a transcription factor required for IP specification and marks this progenitor type (Sessa et al., 2008).
