Sentence examples for transition in prostate from inspiring English sources

This TF is a regulator of epithelial-mesenchymal transition in prostate cancer and stimulates migration and invasion of prostate cancer cells [64].

PDGF induces epithelial-mesenchymal transition in prostate cancer PC3 cells, promotes tumor growth and contributes to the "cancer stem-like" phenotype associated with epithelial-mesenchymal transition [79].

These findings complement earlier studies which found overexpression of KLK4 was associated with an epithelial-to-mesenchymal transition in prostate cancer cells [8] and that KLK4 may modulate interactions between tumour cells and osteoblasts in the development of bone metastases [15].

Id-1 promotes angiogenesis through upregulation of VEGF (Ling et al, 2005), while it also binds to caveolin-1 to induce epithelial mesenchymal transition in prostate cancer cells (Zhang et al, 2007a).

The parallel impact of suppressed Id1 and 3 on these two very different cell lines implies a core role for the Id proteins in regulation of G1/S transition in prostate cancer cells that is independent of known differences between the two cell lines, for example, androgen receptor status, phosphatase and tensin homolog status, p53 and Rb mutations.

TGF-β is a well-known cytokine with a variety of physiological functions such as proliferation, differentiation and immune response and in addition it plays a major role in cancer progression by inducing epithelial-to-mesenchymal transition (EMT) in prostate cancer and promoting metastasis to the bone, the final step in prostate cancer progression [ 35, 36].

The transition to tumourigenesis in prostate epithelial cell lines results in major changes to Cho metabolite release into the medium and PKC signalling to phosphatidylcholine turnover.

Ezponda et al. reported that MMSET could activate TWIST1 to promote an epithelial-mesenchymal transition and invasion in prostate cancer [ 37].

Therefore, 10 of 13 (77%) of the GWAS genes were differentially expressed in the transition from normal prostate to prostate cancer that is higher than one can expect to detect among randomly chosen 13 genes −1.1 (χ2 = 20.9, df = 1, P<0.0001).

We have identified a panel of genes regulated by androgens in human transition zone prostate tissue in vivo.

In the past decade, many studies were conducted to investigate the mechanism that causes the transition of hormone dependency in prostate cancer [ 3, 4], including low throughput experiments, such as Western blot, real-time PCR, and Northern blot [ 5, 6], and high-throughput studies including microarray experiments [ 7- 9].