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All data show that ERK3 is essential for spindle stability and required for metaphase-anaphase transition in mouse oocyte meiosis.
Our data suggest that ERK3 is crucial for spindle stability and required for the metaphase-anaphase transition in mouse oocyte maturation.
In this study, we for the first time demonstrate that ERK3 is important for MI spindle stability and required for the metaphase-anaphase transition in mouse oocyte maturation.
Dinah Levy and colleagues from the Bissell laboratory (Lawrence Berkeley National Laboratory, Berkeley, CA, USA) reported the effects of isoforms of c/EBPβ (CCAAT enhancer binding protein beta) in epithelial to mesenchymal transition in mouse mammary epithelial cells.
A loss of E-cadherin results in a loss in all epithelial features and is sufficient to accelerate the adenoma-to-carcinoma transition in mouse tumor models, indicating that loss of E-cadherin may be a rate-limiting step in tumor progression [ 14].
There is limited evidence on the role of this protein in cancer, but results of Pofut2 knockout mice showed that the loss of the protein leads to epithelial-mesenchymal transition in mouse embryogenesis, suggesting an important role of the protein in cancer [ 41].
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In fact, recent studies have demonstrated significant pulmonary and cardiovascular toxicity of SWCNT associated with a robust inflammatory response and early onset of fibrotic transition in mice [53], [63], [64].
Interestingly, Nr1h4 is thought to modulate the fasting-re-feeding transition in mice [ 58].
Indeed, it has recently been proposed that the H2B histone variant TH2B controls the histone-to-protamine transition in mice (Montellier et al., 2013).
The likeliness of Vertnin's candidature is strongly supported by the previous demonstration that structural integrity of the somites, as well as somitic expression of genes such as Gli3 and Fgf10, are required for the proper formation of the mammary line and glands at the axial level of thoracic/abdominal transition in mice [ 27].
For example, DKK1 and PSEN1, the most contributive genes to network transitions in both species, showed nearly 100-fold higher probabilities in the ESC-to-EB transition than the EB-to-ESC transition in human cells, but showed similar probabilities between the two transitions in mouse cells (Figure 3, details in Table S3).
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