Sentence examples for transition in melanoma from inspiring English sources

BMP7 could inhibit normal melanocyte growth and tumor growth of human uveal melanomas [ 35, 36], and could inhibit metastasis by inducing mesenchymal-to-epithelial transition in melanoma cells [ 37].

Wnt5a promotes epithelial-to-mesenchymal transition in a melanoma cell line [5].

The recent identification of driver mutations in the promoter of the telomerase reverse transcriptase (TERT) gene with UV-induced cytidine-to-thymidine transitions in cutaneous melanoma prompted us to investigate whether these mutations also occur in uveal melanoma.

We analyzed the effect of Wee1 inhibitor PD0166285 described first by Wang in the G2 transition in the B16 melanoma cell line.

In melanoma, the transition of a lesion from the noninvasive radial growth phase (RGP) to the invasive and metastasis-competent vertical growth phase (VGP) is a major step in tumor progression, and PAR expression is implicated in the RGP-VGP transition process [ 249].

Here, we applied this technique to visualize retrograde flow and the lamellipodium/lamellum transition in spreading fibroblasts and melanoma cells (Fig. 1).

We find that the bundling activity of Eps8 is required for promoting the mesenchymal-to-leader bleb transition in confined, non-adherent melanoma cells.

We observed that CYLD induces a delay in the G1/S transition of the cell cycle, both in melanoma cells as well as in keratinocytes.

Melanoma tumors M42 and M43 showed heterozygous single point mutations at TP53 introns 1 and 2. The C to T transition at position 11701 in intron 1, observed in melanoma tumor M42, contrasted with the absence of this transition in autologous PBLs.

Whereas we uncovered an epigenetically fixed gene expression signature in melanoma cells attesting their transition through an episode of DNMT1 depletion, no similar gene expression signature was observed in other tumor types.

We detected only two mutations in exon 1 of the CDKN2A gene, both in melanoma tumor M13: G to A transition at position 149 producing a stop codon [ 25], and the novel missense mutation Leu298 (leucine → proline).