We further evaluated primary melanomas of varying Breslow's tumor thickness to determine that the transition in expression occurs at different thicknesses for different genes suggesting that the "transition zone" represents a critical time for the emergence of the metastatic phenotype.
Finally, CEP gene expression in Oryza sativa was examined using publicly available RNA-Seq datasets to reveal a developmental transition in expression of CEP genes from OsCEP6 in the booting panicle to OsCEP5 in the flowering panicle, strongly suggesting these genes play a role in panicle development.
This article presents a new method for analyzing microarray time courses by identifying genes that undergo abrupt transitions in expression level, and the time at which the transitions occur.
Transition in cytokine expression profile was associated with a diminished expression of inducible nitric oxide synthase and an increased expression of arginase 1 in F4/80(hi) macrophage subset.
Based on the intermediate level of CD16 expression during osteoclastogenesis in vitro-b), we assumed that a similar transition in CD16 expression might also occur in vivo.
Finally, we found that the transition in CSPG expression in the striatum, a potential marker for the maturation of circuitry underlying both exploratory and motor behaviours, is also significantly accelerated in enriched mice.
The transition in CSPG expression described in this study occurs at a time consistent with the initial onset of striatum dependent behaviours, such as the initiation and maintenance of goal directed, coordinated movements.
Both have been extensively studied, first to understand the maternal:zygotic transition in gene expression patterns, and second to characterize differentiation of cells, organs, and tissues.
In addition, we included children (n = 66, with age ranging from 9 to 10 years) in the validation set to add the information on the transition in miRNA expression from infancy to adulthood.
To examine if any of these auxin-responsive genes function in mediating the observed auxin level changes during the ripening transition in grape, expression of these ARFs was examined in the pericarp of low- and high-SB berries from 1-wk PV clusters, which had lower and higher auxin levels, respectively.
Moreover, the peak in H3K9me3 occurs at transcriptional transitions in frq expression from highly expressed to repressed (e.g., light to dark transition), implying that DIM-5 is likely involved in muting frq expression via facultative heterochromatin formation.
