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Results are presented for a transition cycle design that compares performance of multi-cycle optimization to successive, single cycle optimization with regard to reducing levelized fuel costs.
The study revealed striking differences between the molecular interactions of substrate and inhibitor; inhibitors showed a tendency to maintain stable binding interactions during the catalytic transition cycle.
In proteoliposomes, the average time of a transition "cycle" in the absence of substrate (τ free) is 15 s (=2/(0.13 s−1)), where the factor 2 comes from the two FRET signals in each cycle.
In the presence of substrate gradient, the observed average time of a transition "cycle" (τ obs) is 20 s (=2/(0.1 s−1)), and the average time of a substrate uptake cycle (τ influx) is 30 s (=1/(0.03 s−1)).
Assuming that the partition function f < 1/10, one may estimate that ∆G D < −2.3 RT. (iii) In proteoliposomes, the average time of a transition "cycle" in the absence of substrate (τ free) is 15 s (=2/(0.13 s−1)), where the factor 2 comes from the two FRET signals in each cycle.
Are we still too early in the 'Midlife Women Rock' transition cycle?
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State-of-the-art core physics tools have been employed to establish fuel inventory and reactor physics performances for equilibrium and transition cycles.
Comparison is made between conventional methods of processing the residue data points, which may be non-conservative, and a more versatile method, presented by Amzallag et al. (1994), which allows transition cycles to be processed accurately.
In order to obtain probabilities corresponding to one-month transition cycles, rates were converted using time-dependent monthly probabilities [ 41].
Quarter-yearly transition cycles were assumed because significant changes in tumour states could occur after 90 days and long term adverse effects could be apparent.
Face validation resulted in model adaptations with respect to development and treatment of AEs, length of transition cycles as well as assumptions concerning resource utilisation.
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