Sentence examples for transition by regulating from inspiring English sources
pRb is a tumor suppressor that regulates the cell cycle at the G1/S transition by regulating the E2F family of transcription factors (reviewed in [9]).
Also, miR172 functions in promoting vegetative phase transition by regulating the APETALA2-like gene glossy15 [ 29].
This is in agreement with the observation made in somatic cells that Klf4 delays and Klf5 accelerates the G1/S transition by regulating the expression of cyclins, cyclin-dependent kinases (Cdk) and Cdk inhibitors.
Since APC has been shown to control the G1/S transition by regulating the β-catenin/TCF transcriptional targets c-myc and cyclin D1 [ 22], these results suggest that APC suppression in these invasive breast cancer cells impacts neither β-catenin-mediated transcription nor proliferation.
Wnt1/ β-catenin signaling has been reported to control G1/S transition by regulating cyclin D1 transcription.
Furthermore, we have established an important function for CHD4 in cell-cycle control at the G1/S transition by regulating p53 deacetylation.
Constitutively activated Akt has been linked to epithelial-to-mesenchymal transition (EMT) by regulating MMPs resulting in reduced cell-to-cell adhesion, increased motility and invasion.
Rac1 activation can promote both EMT and mesenchymal epithelial transition (MET) by regulating assembly and disassembly of adherens junctions, and thereby has the ability to either prevent or facilitate tumor metastasis and secondary tumor formation.
Interestingly, in different cellular contexts within the wing disc, Notch can either promote cell proliferation or can block the G1-S transition by negatively regulating the expression of dmyc and bantam micro RNA.
The occupancy of these sites could functionally drive a cell cycle transition - for example, by regulating transcription.
These findings indicate that TRPM7 is required for cellular proliferation of pancreatic adenocarcinoma by regulating transition from G1 to S and G2 to M in the cell division cycle.
