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The tumor suppressor function of CYLD in skin is due to the reduced proliferation rate mainly through a delay in the G1 to S phase transition by reducing cyclin D1 expression levels [2], [10], [31] in a NF-κB dependent signaling pathway.
Given that aggregating aSyn no longer interacts with SERF1a, we suppose that this initial short-lived association is sufficient to lower the thermodynamic barriers of amyloid transition by reducing the lag phase and thus leading to an earlier elongation phase.
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Dynamic mechanical analysis indicates that the incorporation of CNTs affects the glass transition behaviour by reducing the height of the tan δ peak considerably.
FLC inhibits the floral transition partly by reducing expression of a key flowering-time integrator, FT [28].
To assess the impact of sample size on the performance of the feature selection, we systematically reduce the number of observed state transition events (by reducing the number of genealogies) and calculate the statistical power of our method, i.e. the probability to detect a certain effect if present in the data (Fig. 5 a, e).
Reducing this transition by 10% reduced R0 by 13.4% and 15.2% at Point Reyes and Riverside, respectively (Table 3b).
Signing can also ease a toddler's transition to speaking by reducing the frustration of trying to pronounce words like "toothbrush," or to express concepts like needing a diaper changed.
The alpha helical content of purified PrP is decreased by binding to PPS, which has been proposed to increase the susceptibility of the protein to conversion in cell free assays by reducing the transition barrier [38].
Metformin also stabilizes mitochondrial functioning by reducing the transition pore opening, which protects against ischemia- [18], oxidant- [19, 20], or hyperglycemia-induced [21] cell death.
Launching the policy idea on behalf of the Welsh Conservatives, Shadow Education Minister Angela Burns believes it could "make HE (higher education) more accessible to people from less well-off backgrounds" by reducing the transition from "learning to earning".
Top ten finishers in 'Ironman Hawaii' might further improve their overall race times by reducing their transition times.
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