Sentence examples for transition by downregulating from inspiring English sources
The phrase "transition by downregulating" is correct and usable in written English.
It can be used in contexts related to biology, biochemistry, or any field discussing changes in regulation or expression of genes or proteins. Example: "The cell can transition by downregulating certain genes to adapt to environmental changes."
The RNA-binding proteins FCA and FPA are known as positive regulators of the floral transition by downregulating expression of the MADS box floral repressor FLC (Koornneef et al. 1991).
We found using Western-blotting that let-7g can regulate epithelial-mesenchymal transition (EMT) by downregulating K-Ras and HMGA2A after reexpresssion.
Mechanically, solanine promotes the opening of mitochondrial membrane permeability transition pore (MPTP) by downregulating the Bcl-2/Bax ratio; thereafter, Cytochrome c and Smac are released from mitochondria into cytosol to process the caspase-3 zymogen into an activated form.
Furthermore, DDR2 mutation could induce Epithelial-to-Mesenchymal Transition in lung SCC cells by downregulating E-cadherin expression.
We have recently reported that epithelial-to-mesenchymal transition (EMT) promotes α-tubulin detyrosination by downregulating expression of TTL and that detyrosinated tubulin accumulates at invasive tumor fronts in patient samples [ 11].
Our results demonstrated that physiological concentrations of sorafenib induce a dose-dependent inhibition of proliferation by downregulating key G1/S transition proteins CDK2 and cyclin D1 in all cell lines.
ZEB1 is predominantly known for its ability to modulate epithelial to mesenchymal transitions (EMT) in development and cancer by downregulating E-cadherin and other genes encoding cell adhesion and basement membrane proteins [29], [30].
By downregulating E-cadherin and upregulating expression of TWIST1, it enhances epithelial-mesenchymal transition and metastasis in colon cancer [ 35].
Bioinformatic target gene predictions followed by experimental target gene validations revealed that miR-17, -20a, and -106b act in a common manner by downregulating an overlapping set of target genes mostly involved in regulation and execution of G1/S transition.
It has been shown that progesterone can antagonize neuronal estrogenic effects by downregulating estrogen receptors [63].
It inhibited in vitro cell proliferation and migration through Matrigel by downregulating proteolytic cascades.
