Sentence examples for transition at codon from inspiring English sources

A functional G to A polymorphism in the fourth exon of COMT gene results in a valine to methionine amino acid transition at codon 158 (COMT Val158Met polymorphism) leading to thermolability [26], [27] and lower activity of the enzyme.

The PTPN22- 1858C/transitionon at codon 620 eliminates a restriction site for RsAI in the 1858T allele.

In PPARGC1A, a polymorphism that consists in a transition at codon 482 (rs8192678) was associated with chronic diseases [ 8– 13].

First reported in 1989, this human G to A transition at codon 200 has arisen independently at least four times in human history [ 19, 20].

Sequence analysis of AN0273 in MGG1.124 showed it harbored a C -> T transition at codon 163 leading to an early stop codon in the predicted ORF.

In the EC group, the K-RAS mutations were one G>A transition at codon 13 and a T>C transversion (Supplementary data).

Moreover, transitions at codon 248 were experimentally induced with an NO-releasing compound [110] while mutations at codon 273 were found to be strongly associated with diets high in red meat and fat [44].

The results showed that the APC gene of explant cultured cells from OSF patients (8/8) had a CGA-to-GGA transition mutation at codon 498 that resulted in an Arg-to-Gly missense mutation (P <.01).

In both cell lines, p53 sequencing analysis provided evidence of C>T transition (arrow) at codon 273 in exon 8, which leads to an amino-acid change from Arg>Cys.

Based on the method described by Gotoda et al. [ 54], a PCR followed by digestion with endonuclease MspI was used to detect the A to G transition polymorphism at codon 223 of LEPR gene.

Interestingly, different nucleotide transversions or transitions at codons 465, 473, 482 and 518 individually caused three or four different amino acid substitutions at each codon (Table 2).