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AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells.
We previously reported that Polo-like kinase 2 (Plk2) is activated near the G1/S phase transition, and regulates the reproduction of centrosomes.
Cadherin-11 is expressed in the mesoderm-derived tissues, associated with the epithelial-to-mesenchymal transition, and regulates osteogenesis [ 25] and cancer metastasis to the bone [ 26].
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Taken together, these results show that transcriptional and gene-specific translational control dominate at different stages of the cell cycle (transcription at the G1-to-G2 transition and translational regulation dominating at the more rapid G2-to-M transition) and regulate a distinct set of genes.
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.
The recruitment of additional gamma-tubulin to the centrosomes occurs during centrosome maturation at the G2/M transition and is regulated by the mitotic kinase Plk1.
The recruitment of additional γ-tubulin to the centrosomes occurs during centrosome maturation at the G2/M transition and is regulated by the mitotic kinase Plk1.
These findings closely correlate with our previous immunohistochemical studies on SS, wherein TGF-β1 was found to induce mesenchymal epithelial transition and to regulate biphasic differentiation.
Gadd45α is known to be upregulated in response to a variety of cell stresses in order to elicit cell cycle arrest at the G2-M transition and to regulate the apoptotic response.
Collectively, these results suggest that Notch3 stimulates cell cycle progression by promoting the G1-to-S phase transition, and that it regulates the ERK pathway in RMS cells.
Cyclin E is an essential protein for the G1- to- S phase transition and it is regulated by Cyclin D1.
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CEO of Professional Science Editing for Scientists @ prosciediting.com