In another study, Jiao et al. [ 37] investigated the mechanisms by which BaP accelerates cell cycle progression (G1/S transition) and induces cell proliferation in human embryo lung fibroblasts.
MiR-26a greatly suppresses the enhancer of zeste homolog 2 (EZH2), inhibits cell proliferation, blocks G1/S transition, and induces tumor cell apoptosis [ 38].
Exposure of p53wt MCF-7 breast cancer cells to p28 induces a post-translational increase in the level and activity of p53, inhibits the cell cycle at the G2 M transition and induces apoptosis, but not in the isogenic p53dom/neg cell line MDD2 (Shaulian et al, 1992; Yamada et al, 2009).
The binding of Cu2 + with nitrogen atom of CN moiety in these three compounds can inhibit the photo-induced electronic transition process and induce the ratiometric-absorption and fluorescent OFF ON response to Cu2 +.
p21Cip is regarded as universal inhibitor of cyclin-CDK complexes [ 29- 31], thus blocking the entry of cells at the G1-S-phase transition checkpoint and induce apoptosis [ 32].
Introduction of PPO chain to the TFSI salt group resulted in lower the glass transition temperature (Tg) and induce the salt dissociation.
Everolimus (RAD001) is an oral mTOR inhibitor derived from rapamycin, which blocks the activation of S6K1 and 4E-BP1, thereby inhibiting cell growth, proliferation, and G1 S transition, and inducing apoptosis (Boulay et al, 2004).
IL-12, an indicator of antigen-specific CTL priming, can polarize Th0 to Th1 transition and subsequently induce antivirus and antitumor immune responses [ 29].
