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We have extensively reworked the Introduction and Discussion of the manuscript to focus on the divergent models of the relationship between the glass transition and functional dynamics.
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We also assessed changes in the expression of markers promoting epithelial to mesenchymal transition and performed functional studies.
Differentiation of tubular epithelial cells into mesenchymal cells (epithelial to mesenchymal transition) and the functional and phenotypical progression of endothelium to mesenchymal cells (endothelial to mesenchymal transition; EndMT) have been proposed as potential sources of myofibroblasts responsible for renal fibrosis after injury.
Nuclear morphogenesis is a dynamic process requiring successive and timely transition of structural and functional elements both outside and within the nucleus [7], [75], [76].
In this transition, expression changes and functional chagnges of the camera eye specific candidate genes might have been contributed to the acquisition of the eye compnents.
The strong magnetoelastic interaction in ternary X2YZ Heusler alloys is reponsible for the appearance of magnetostructural phase transitions and related functional properties such as the magnetocaloric and magnetic shape-memory effects.
We investigated the differential expression of NAC and YABBY regulated genes between stage 3 (before the functional transition) and stage 6 (after the functional transition) using our RNA-Seq data.
We investigated the differential expression of gene models identified by ChIP-Seq between stage 3 (before the functional transition) and stage 6 (after the functional transition) using our RNA-Seq data.
We defined differentially expressed genes at each transition and subsequently detected functional modules.
In fact, PLK1 is an early trigger for G2/M transition and supports the functional maturation of the centrosome in late G2/early prophase.
This striking phenotypic and functional transition and its implications for CF pathogenesis are discussed in more details below.
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