Because PGC specification and establishment of the germline is impossible without Blimp1, it is reasonable to conclude that reversion of epiSCs to rESCs does not transit through an equivalent PGC-like state.
Since several aminoacids can fulfill such biochemical requirements, functionally equivalent transit peptides can accumulate non-synonymous substitutions particularly fast, and may bias genome-wide and gene-specific estimates of aminoacid substitutions.
For me the primal experience of Boston dread has less to do with shame and guilt than traffic and transit -- the automotive equivalent of the eternal torment of Charlie on the M.T.A. My primal Boston experience came on one awful weekend in young adulthood that scarred me forever.
Perhaps, the same role is played by epsinR in detoxifying human cells of WT α-syn, i.e. epsinR causes sorting of WT α-syn into endosomal compartments that then transit to the lysosome (mammalian equivalent of the vacuole), where WT α-syn is degraded.
By 1985, the turnstiles were collecting 13,000 slugs per day, roughly the equivalent of all public transit ridership in Kansas City.
In Europe, notes a Detroit executive, their equivalent might drive a Transit van, but would not use that to take a partner to dinner.Today's pickups demonstrate pragmatism.
Senators from the Washington suburbs support the Baltimore subway because continued Maryland support of the Washington Metro is predicated on equivalent support to mass transit in the Baltimore area.
