Thus, tumor progression might require transient up- or down-regulation of target gene expression depending on mutational load and local environmental conditions.
For this classification analysis, we choose three major synexpression groups (sustained up-, transient up- and down-regulated from the hierarchical clustering) as different classes.
It has been suggested that the large progesterone-induced [Ca2+]i transient (up to 40 s) is accompanied by a burst of HA in some cells (Gakamsky et al., 2009; Servin-Vences et al., 2012).
Of these, 136 genes, nearly 40% of the total number of differentially regulated genes identified in the study, displayed transient up or downregulation that would have been missed by only comparing fully differentiated parasites.
The remaining genes partition into 15 clusters showing sequential transcriptional induction (that is, up-regulation from zero FPKM) on D0, D3 or D9 (clusters 5-7), up-regulation of already expressed genes (cluster 8), sequential transcriptional down-regulation (to zero FPKM; cluster 9-11), and transient up- or down-regulation (cluster 12-19).
J Am Soc Nephrol 1998;9 581 (abstract); Koshiba M, Apasov S, Sverdlov V, Chen P, Erb L, Turner JT, et al. Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes.
A transient up-regulation of CD69 is followed by down-regulation of IL-7R and CD62L.
These genes also generally had a high positive value along PC-2, indicating a transient up-regulatory trend.
These data emphasize that an irradiation-induced, transient up-regulation of HLA-E on macrovascular ECs might confer protection against NK cell-mediated vascular injury.
Using mCherry as a reporter we showed that PmbtB expression progressively decreases during hypoxia, in contrast to LacZ reporter which suggested transient up-regulation.
In the lesioned area, we observed an early and transient up-regulation of GPR17 in neurons expressing the cellular stress marker heat shock protein 70.
