When transiently applying the concept of permissive hypotension, it would be helpful to know at which arterial blood pressure terminal cardiovascular collapse occurs.
Even when transiently applying the strategy of permissive hypotension, these arterial blood pressure levels should never be reached or tolerated, but rather an individual safety limit (for example, one or two standard deviations) above these arterial blood pressure levels should be maintained.
Taken together, MST1/2 and LATS1/2 kinases should be considered as potential drug targets for regenerative medicine, applied transiently in conditions such as recovery from myocardial injury.
The induced electrical field is able to transiently modulate cortical neuronal activation, and, when applied during an object naming task, this neuronal modulation can cause transient, audibly detectable impairment of language [ 4, 8].
For this purpose, the authors transiently overexpressed and silenced ZNF24 and then applied microarray assay in order to identify target genes.
Examples of "winds" could include externally applied cytokines or drugs that transiently alter network components and thereby influence the trajectory of cell phenotype changes, for example, differentiation.
When a calcium ionophore is applied to Dictyostelium cells, actin transiently assembles at the cortex, suggesting that the entry of Ca2+ can be a trigger for actin assembly (Yumura, 1993; Yumura, 1994).
In order to test this hypothesis we examined yellow fluorescent protein-tagged hippocalcin (hippocalcin-YFP) translocation induced in transiently transfected hippocampal cultured neurons by iontophoretically applied and synaptically released glutamate.
When the attached bead was displaced, the force applied to the focal adhesions transiently rose, and then declined in less than a few seconds, indicating a tension decline in the stress fibers, probably due to a partial destruction of the linkage among the actin fibers within the stress fiber, which would decrease its elastic modulus.
As a proof of principle we applied this assay to HeLa cells transiently expressing early endosome associated Rab5a [11,24].
