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Radioimmunotherapy resulted in dose-dependent, transient weight loss and myelotoxicity.
During the treatments, the animals in the bacterially treated groups showed a transient weight loss.
HKx31-infected mice showed transient weight loss over the first week of infection but recovered thereafter and no animals succumbed to infection.
For example, transient weight loss in the period immediately following treatment occurred in all PCP-treated groups of mice, with absolute body weights remaining lower than control mice until early adulthood.
Interestingly, a single immunization was able to protect mice from virus-induced death, albeit mice administered lower doses of VLPs or rHA had viral replication in the lungs and transient weight loss.
Ferrets inoculated with the CA04/09 (rgCA04/09) virus, created by reverse genetics, showed no substantial clinical signs and only displayed transient weight loss during the first week of infection (Table 1).
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Toxic side-effects were limited to minor, transient weight losses.
Transient body weight loss and bone-marrow suppression were observed.
Protection from lethal challenge with VN/04 virus was also observed with doses containing as low as 0.1 µg H5 HA in VLPs despite a transient body weight loss.
Immune sera at dilutions up to 100 fold conferred protection with only a transient body weight loss whereas a 50 fold dilution provided protection without any loss in body weight.
Groups of mice immunized with either inramuscular or microneedle vaccination without trehalose formulation (MN and IM) showed significant illness as determined by loss in body weight up to 15 to 17% whereas the intramuscular group with trehalose (IM+T) showed a only transient body weight loss of 5%.
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