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Our work presents a model in which dosage compensation buffers gene amplification through aneuploidy to provide a natural, but likely transient, route to rapid phenotypic evolution.
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First of all, empirical analyses based on proper indicators and statistical tests are suggested in order to evaluate how the collected data have to be handled in order to eliminate transient route-choice observations.
The system is simulated under transient sea route weather conditions and loading/unloading conditions, and compared with the conventional system design.
The cells used chromosome duplication as a crude solution to these stresses, representing a transient escape route at the individual gene level until more efficient and permanent solutions could be developed.
Most of the clients at Donna's Ranch are transients, drivers en route from one place to another.
Another route to transient Nm immunity is contracting Neisseria lactamica (Nl), a commensal pathogen.
We suggest that the escape route involves transient formation of a Cys53−Cys55 disulfide, although we have not confirmed this experimentally.
A major challenge when analysing the pathway of amyloid fibril formation is identifying and characterizing transient oligomeric intermediates en route to larger aggregates and fibrils (Fig. 2e).
Our data suggest that GC-1 interaction with DnaJB6 is transient, most likely in route to the outer segment, since we were not able to co-precipitate DnaJB6 with GC-1 from whole retina lysates.
Interestingly, E346 and D924 flank the entrance of each of these water wires; as mentioned earlier, both these side-chains are likely to be protonated in the L and T states and deprotonated in the O state, which suggests that E346 and D924 facilitate proton uptake by providing transient binding sites en route to D407/D408 (Fischer and Kandt, 2011).
Nonhuman primates (NHPs), such as rhesus monkeys (Macaca mulatta) or common marmosets (Callithrix jacchus) inoculated with MERS-CoV via combined intratracheal, intranasal, oral, and ocular routes, develop transient respiratory disease with little or no viremia although lethal disease was observed in a small number of marmosets [1 4].
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CEO of Professional Science Editing for Scientists @ prosciediting.com