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Methods that have been tested to induce transient proliferation of HCEC will also be presented.
Such clusters seemed to have arisen through the in vivo, transient proliferation of single donor cells, as supported by the sporadic expression of Ki67 observed in HuN+ cells (Fig. 3E and inset).
Such a transient proliferation response is compatible with the activation of neural precursors with limited self-renewal potential resulting in a transient recovery followed by exhaustion of the precursor pool.
Thus, engulfed cells show transient proliferation of peroxisomes.
Once specified from the HE, HSCs leave the dorsal aorta and move toward the placenta and fetal liver for transient proliferation, after which they are finally able to colonize the bone marrow as the most important adult hematopoietic organ.
In this model, presentation of donor apoptotic cell-derived allopeptides by immature/semi-mature DC in the spleen promoted transient proliferation of anti-donor CD4 T cells unequipped for homeostatic survival.
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Intriguingly, we also found sporadic MAP2+/humanKi67+ cells at 3 months post ischemia, which completely disappear at 4 months, indicating that at least a fraction of IhNSC-Ps undergo transient short term proliferation, also favoured by the local specific environmental cues [33].
It is known from several organisms, that transdifferentiation occurs by the following steps: transient dedifferentiation, proliferation and differentiation into the new linage [ 1, 51].
As seen in Figure 2, there was a significant increase in the proportion of 2BS cells in the S-phase between 2 and 6 hours after exposure to 50 mGy X-irradiation compared to unexposed controls, suggesting that LDR promoted transient cell proliferation.
Oncogene activation causes transient hyper-proliferation that results in genotoxic stress and activation of DNA damage responses (DDRs) that initiate cell cycle exit.
The transient effect on proliferation curves of YAC-1 cells and Ki-67 proliferation indexes disappearing at the fourth week of culture at a total cumulative dose estimated at 3.6 cGy also suggests an adaptive response.
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