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Such an order of events corresponds to the pausing model of transcription termination where it is envisioned that G-rich sequences, located immediately downstream of the poly(A) site, cause a transient pause in Pol II progression that effectively enhances 3′ end processing (Gromak et al., 2006).
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In three of the seven PCs, transient pauses in firings of simple spikes after US presentations were also observed.
It was considered that simple and complex spikes originated from the same PC when a transient pause (∼15 ms) in simple spike firing followed each complex spike (Fig. 1).
You suggest that the abundant transient pausing on mRNAs, in the previous published study, caused by other effects, probably made it impossible to see the relatively more subtle differences in ribosome residence time derived from differences in codon recognition.
Holroyd and Coles's (2002) reinforcement learning theory states that reward prediction errors lead to transient pauses of DA release in the anterior cingulate, which in turn generates a FRN or an ERN.
Genes with the most paused PolII lack a significant +1 nucleosome signal and are paused by separate factors (GAGA and NELF) whereas less stably paused, more processive genes have a strong +1 nucleosome signal that causes more transient pausing.
Transient pausing can occur with little or no retrograde motion of RNAP.
The pause in-between was meant to counteract such feelings.
Published: June 4, 2015 The rate of peptide synthesis by ribosomes is not uniform along mRNAs and is often punctuated by transient pauses.
This elongation factor stimulates the rate of transcription by suppressing the transient pausing of RNA polymerase II on the DNA template [ 118].
To test whether membrane repolarization is indeed the critical factor to restoring excitability to DNKv4 neurons, we introduced a "pause" in the middle of current injections that allow for transient membrane repolarization.
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