Your English writing platform
Discover LudwigExact(2)
It was considered that simple and complex spikes originated from the same PC when a transient pause (∼15 ms) in simple spike firing followed each complex spike (Fig. 1).
Such an order of events corresponds to the pausing model of transcription termination where it is envisioned that G-rich sequences, located immediately downstream of the poly(A) site, cause a transient pause in Pol II progression that effectively enhances 3′ end processing (Gromak et al., 2006).
Similar(58)
These studies also uncovered unexpected insights into the mechanisms underlying transient pauses.
Transient pausing can occur with little or no retrograde motion of RNAP.
In three of the seven PCs, transient pauses in firings of simple spikes after US presentations were also observed.
Published: June 4, 2015 The rate of peptide synthesis by ribosomes is not uniform along mRNAs and is often punctuated by transient pauses.
This elongation factor stimulates the rate of transcription by suppressing the transient pausing of RNA polymerase II on the DNA template [ 118].
Interestingly, nucleosomes can be barriers to Pol II elongation and cause transient pauses to delay the Pol II traversal (Hodges et al., 2009; Bintu et al., 2012).
Genes with the most paused PolII lack a significant +1 nucleosome signal and are paused by separate factors (GAGA and NELF) whereas less stably paused, more processive genes have a strong +1 nucleosome signal that causes more transient pausing.
Holroyd and Coles's (2002) reinforcement learning theory states that reward prediction errors lead to transient pauses of DA release in the anterior cingulate, which in turn generates a FRN or an ERN.
You suggest that the abundant transient pausing on mRNAs, in the previous published study, caused by other effects, probably made it impossible to see the relatively more subtle differences in ribosome residence time derived from differences in codon recognition.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com