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An ultrasound performed on the following day showed a dilated small intestine with intra-luminal fluid suggestive of a period of transient obstruction.
Whether an earlier transient obstruction occurred cannot be ruled out, however.
The spontaneous recovery suggests that some mice have an acute infection that does not result in permanent biliary obstruction but rather transient obstruction of the bile duct with no subsequent fibrosis.
It has been suggested that the N-terminal region may exert an auto-inhibitory effect leading to the observed activity changes mediated via a direct peptide bond, rather than a transient obstruction of the active site by a mobile N-terminal region (Higgins and Gross, 2011).
Accumulation of motesanib within the gallbladder following the excretion (and reactivation) of its major metabolite, motesanib glucuronic acid [ 38], in the relatively high pH of the bile may result in irritation to the gallbladder or possibly even transient ischemia with subsequent sludge accumulation, transient obstruction, pain, and ultimately, cholecystitis or cholecystitis-like symptoms.
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These include oxidative stress, transient coronary obstruction and oestrogen deficiency, the last explaining the high prevalence of takotsubo cardiomyopathy in women.
Proximal esophageal stenosis induced transient upper airway obstruction with salivary stasis.
Indeed, aerosol delivery might avoid the transient endotracheal tube obstruction and resultant hypoxia and hypotension seen with bolus instillation.
On a simplified yet realistic framework, we assume that the primary site of bacteria interaction with the α-HL nanopore, leading to its transient capture and the obstruction of ions passage across the nanopore, occurs at the trans mouth of the α-HL's lumen.
Upper airway obstruction, especially if transient, is probably one of the better potential indications of helium-oxygen breathing.
Clinically these patients are cured but the question remains wether these patients will develop renal disease in adult life, since it has been recently shown in animal models that transient, neonatal and prenatal, ureteral obstruction induces significant renal deterioration later in life.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com