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For this reason they targeted CSPGs and one week later treated the same rats with transplants of NPC and transient infusion of growth factors (EGF, bFGF, and PDGF-AA).
In NHL patients, lysis of tumor burden may contribute to the mostly mild-to-moderate transient infusion reactions seen in these patients, the frequency of which is greater during the first infusion than in subsequent infusions [ 21, 30].
Early experiments in which a unilateral nephrotic syndrome was induced by transient infusion of PAN in one kidney while preventing its access to the general circulation have demonstrated that proteinuria results from a rapid and direct effect of PAN on the kidney.
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Only a small minority (50 out of 556, 9%) of all AEs recorded were related to NGR-hTNF infusion, being mostly represented by transient, infusion-related grade 1 or 2 chills in 24 patients (65%).
Epratuzumab toxicity consisted primarily of mild to moderate transient infusion-related events during the first infusion, and only one patient with a prior right lung resection for a fungal abscess had a serious event (bronchospasm during infusion), which was treated with parenteral medications.
Transient glucose infusion was only considered in cases of severe hypoglycaemia (< 2 mmol/l) which occurred once in one patient.
12 Thirteen patients (39%) developed transient, cytokine-associated infusion toxicity that resolved by the third infusion.
This Fgfr4-independent repression is transient, as continuous infusion of FGF19 repressed Cyp7a1 expression only in WT, but not in Fgfr4 KO mice (Fig. 1D), and continuous infusion of FGF21 did not repress Cyp7a1 expression in HFD-fed mice [7] or in ob/ob mice (Fig. 4F).
The actions of octreotide on hepatic and systemic hemodynamics are transient, making continuous infusion necessary.
The cytokine profile of a representative patient is depicted in Figure 1 b: cytokine elevation was transient, increasing rapidly after infusion started, peaking at ∼6 hours, and declining to baseline starting at 48 hours, despite ongoing infusion with blinatumomab.
Amifostine has been well tolerated with a low incidence of toxicities, which included nausea and vomiting (3% to 5%) and transient hypotension during intravenous infusion (7%).
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