Persistent infected (PI) animals, originating from a transient infection of pregnant cows or born from PI cows, shed large amounts of virus throughout their lives and ensure viral persistence in the host population.
Indeed, promising results have been obtained in clinical trials of multiple sclerosis and inflammatory bowel disease patients treated with eggs of Trichuris suis, a parasite that infects pigs, and thus causes only transient infection in humans [ 51, 52].
ADCC activity of HGN194, an IgG1 nmAb, may have contributed to the complete protection from systemic infection in our study – perhaps via eradication of small numbers of infected target cells, thus allowing a "Hit and Run" transient infection that primed T-cell immunity.
Pigs become infected around 3 months of age but suffer only a mild, transient infection.
Exposure to Cryptosporidium parvum in healthy individuals results in transient infection that may be asymptomatic or can result in self-limited diarrhoea.
However, most studies illustrating the mechanism are based on exogenous plasmid transient infection rather than manipulate corresponding elements in the host genome by genome editing strategy such as CRISPR/Cas9.
Ct serovar D has relatively low virulence in the mouse and gives rise to a transient infection.
In a second potential pathogenic mechanism, a transient infection may lead to a self-perpetuating innate immune response.
If infection was found only during a single follow-up time point and was not confirmed subsequently, the person was considered to have had a transient infection.
Even if immunization does not completely protect lynxes against transient infection, there is justified hope that the outcome of FeLV infection will be less severe.
This transient infection would further boost heterosubtypic immunity and induce neutralizing antibodies against the exact virus strain circulating in the community, preventing re-infection.
