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We found that a transient immune response stimulated by lipopolysaccharide (LPS) compromised hippocampal neurogenesis and impaired hippocampus-dependent spatial memory.
Most patients had a transient immune response to huKS-IL2.
Following injury, a transient immune response triggers satellite cell activation and muscle regeneration.
Overall, 23 of 26 (88.5%) patients treated with huKS-IL2 developed a transient immune response against the drug.
These results suggest that neuronal ablation is followed by a transient immune response that is not detrimental to recovery.
A large body of literature has determined that in rodents, AAV2 based vectors only trigger a minimal and largely transient immune response.
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Indeed, transient immune responses to cardiac myosin have been reported in healthy individuals after MI, as was first described over one-half century ago ("Dressler's syndrome") [ 46].
GBS and MFS are acute neuropathies thought to result from a transient humoral immune response against host gangliosides in peripheral nerves [ 3].
Interestingly, it was recently shown that acute myofiber damage itself transiently activates muscle-antigen-specific CD8+ T cells in draining lymph nodes, supporting the idea of a transient autoreactive immune response upon muscle injury [ 94].
Didierlaurent, A. M. et al. AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity.
The present trial was designed to establish whether anti-PEG Ab is a transient or persistent immune response to pegloticase during repeated dosing over a period sufficient to achieve clinical benefit.
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