The reason for the switch of primary outcome was the developing insight that transient flaring is an inherent trait of all dose tapering strategies based on disease activity.
A Normal cranial US was found in 415 infants, whereas transient flares or IVH 1 were respectively observed in 59 and 10 infants.
Five patients (31%) experienced a transient 'tumour flare', represented by an increase in bone pain soon after commencing treatment.
Nonhematologic toxicity was limited to transient pain flares in some patients, with no reported cardiovascular, respiratory, renal or hepatic adverse effects or electrolyte abnormalities.
This study also found that over 48% (11/23) evaluable patients had a transient bone scan flare at 3 months that subsequently showed with improvement or stability.
In order to detect and study the ionospheric response to solar flares (transient high energy solar radiation), we have constructed a radio receiver station at Mexico City, which is part of the "Latin American Very low frequency Network" (LAVNet-Mex).
Galaxy CGCG 137-068, a faint spiral galaxy with a central bar, hosted a transient object that flared up about halfway to the galaxy's edge, appearing along one of the spiral arms.
In addition, the occurrence of new lesions might sometimes be transient, reflecting a flare-up phenomenon, such as bone lesions in castrate-resistant prostate cancer or in metastatic gastric cancer (Amoroso et al, 2007; Messiou et al, 2011).
Of note, a "flare" response (transient increase in bone pain) was observed in about one-fifth of patients (seven of 25) during the first week of treatment.
Pain flare, a transient worsening of the bone pain after RT, has been described in previous reports with different incidence rates.
