Sentence examples for transient encounters from inspiring English sources

Proteins assemble to form functional complexes via the progressive evolution of nonspecific complexes formed by transient encounters.

During phase one, CD8+ T cells undergo multiple transient encounters with DCs over several hours.

Thus, stronger binding of TEV to its cleavage sequence may increase the probability of trans-cleavage during transient encounters by stabilizing the protease substrate interaction.

In general, these changes are an order of magnitude longer than the transient encountered during single-phase flow.

Protein-DNA recognition of a nonspecific complex is modeled to understand the nature of the transient encounter states.

We determined the lifetime of the transient encounter complex as a function of magnesium or sodium concentrations.

It does not account for possible downstream conformational changes or other factors that may significantly influence how an initial transient encounter matures or the stability of the resulting protein DNA complex.

Analysis of several high-flux transition pathways reveals that p53 c-terminal regulatory domain forms a transient encounter complex at a distal site on sirtuin before formation of a stably bound β-sheet.

The characterisation of the conformational dynamics of biomolecules from soluble PRE was first reported over thirty years ago.[ 45] PRE can report on conformational exchange in biomolecules and biomolecular complexes (e.g. domain reorientation, alternative binding modes, transient encounter complexes).

Thus, we hypothesized that background could be reduced by decreasing the affinity with which TEV binds its cleavage sequence (i.e., increasing KM) and/or by reducing the rate at which cleavage occurs once TEV has bound its cleavage sequence (i.e., decreasing kcat), such that the probability of trans-cleavage occurring during a transient encounter is reduced.

Upon binding of pKID to the KIX domain, an ensemble of transient encounter complexes forms, which appear to be stabilized primarily by hydrophobic contacts and evolve to form the fully bound state via an intermediate state without disassociation of the two domains.