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When the CCHCR1 transgenic risk mice, with downregulated vitamin D receptor [30], were wounded and PMA-treated, KC proliferation was reduced [3], suggesting less active AP-1 or STAT3 signaling.
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The transgenic plant risk assessment adheres to a weight-of-evidence approach that considers comparative risks.
For the transgenic plant risk assessment, problem context and definition together comprise the problem formulation and scoping element of the risk assessment.
Implicit to transgenic plant risk assessment is a case-specific consideration developed on the basis of comparability [ 8].
Similarly, because hazard is generally absent, consideration of a threshold effect through dose-response is insufficient for the needs of transgenic plant risk assessments.
Here we discuss the needs for advancing transgenic plant risk assessment by appropriately interfacing science with the needs for decision-making.
Appropriate problem formulation provides the means whereby existing guidance for transgenic plant risk assessment can be shaped to address the specific context of the environmental release of a transgenic stress tolerant crop.
Problem formulation has been widely considered from the perspective of transgenic plant risk assessments [ 20, 29, 30, 34] as a means to identify the nature of questions that are germane to a given case of risk assessment and to arrive at a practicable analytical plan for risk characterization.
Transgenic biofeedstock crop risk assessments can benefit from current best practice for science and decision-making at the risk management-risk assessment interface [ 7, 30].
"If small studies on transgenic crops imply risk or harm, an additional level of rigor must be employed to ensure reproducibility and hard significance of the primary findings," says Kevin M. Folta, an associate professor in the University of Florida Horticultural Science Department.
As part of the safety assessment for transgenic crops, the risk for an introduced protein to be a food allergen is considered [ Codex Alimentarius Commission 2003; Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO) 2001; Goodman et al. 2005; Kimber and Dearman 2002; Mendelsohn et al. 2003; Metcalfe 2005; Metcalfe et al. 1996].
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