Sentence examples for transgenic mutation from inspiring English sources

These results indicated that chrysotile asbestos were able to produce deletion mutations in gpt delta transgenic mutation assay system.

We developed a simple, cost-effective, and high-throughput method to characterize the mutation spectrum of a transgenic mutation reporter locus in rodents using targeted NGS.

Transgenic mutation reporter rodent models, such as Muta™Mouse [ 1], enable the detection of spontaneous and induced mutations in vivo (reviewed in ref. [ 2]) and the identification of chemical mutagens.

These datasets contain information on changes in gene expression in response to perturbations of cells, such as stimulation with a small molecule or alterations due to a transgenic mutation.

Such transgenic mutation assays involve scoring of mutations at transgenic lacZ or lacI sequences carried on a lambda phage shuttle vector that has been stably integrated into the rodent genome.

A major advantage of the transgenic mutation system lies in its ability to provide reliable and reproducible assessments of in vivo mutagenicity in any organ or tissue [ Heddle et al., 2000; Nohmi et al., 2000; Thybaud et al., 2003].

These results provide direct evidence that asbestos fibers induced kilobase pair deletion mutations in a transgenic mouse mutation system, and that these were mediated by oxyradicals.

The transgenic rodent mutation reporter assay provides an efficient approach to identify mutagenic agents in vivo.

In the present study we adapted the gpt delta transgenic mouse mutation system to evaluate the genotoxicity of chrysotile in gpt delta mouse primary embryo fibroblast (MEF) cells.

So far, important insights into the mechanisms of RA-related destruction of cartilage have already been obtained from several animal models of arthritis, including destructive arthritis induced by various antigens, transgenic and mutation models and immunodeficient mice [ 12- 16].

Although DEHP is generally considered to be non-genotoxic, 12 lacZ plasmid-based transgenic mouse mutation assays 19 and several in vitro studies have suggested the genotoxic potential of DEHP.