For example, although the United States issued a patent in 1988 for the transgenic "Harvard Oncomouse," this issue is as yet unresolved in Canada.
Since the source of TSCs in transplanted adult muscles was not known with certainty, we examined this issue using transgenic mice with fluorescently-labeled TSCs [16].
In this MS, R* deactivation is of course a deciding factor because they deliberately slowed it down by making StoA and TtoA mutations, so now variability of R* deactivation, confounded in this work by degeneration issue and transgenic expression level, shows up in response duration and kinetics".
In addition to these issues with transgenic constructs, genetic background may also impose variability in behavioral studies [30].
A few studies have addressed these issues using transgenic mouse models (Funakoshi et al., 1998; Guillemot et al., 2007; Koppel et al., 2009; Timmusk etal., 1995, 1999).
Containment of transgenic rice is an urgent issue.
In this study, we address this issue by generating transgenic Xenopus that lack functional clocks specifically in either rod or cone photoreceptor cells.
We are currently generating a Gal4-RARA transgenic mouse to circumvent this issue.
We have investigated this key issue by exploiting transgenic mice overexpressing Ucn3 (UCN3OE) widely throughout the brain.
To address this outstanding issue, we used transgenic mice in which the E-GFP gene has been inserted between the endogenous CTGF promoter and gene.
