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Fitness benefits of the transgenes were similar among the F5 F7 populations, indicating the stability of transgenic effects.
Also studied was a transgenic line included as a control for transgenic effects known as Harry [18] and three lines of mice in which the prion protein had been modified.
The non-transgenic littermates (wild-type) served as control for transgenic effects.
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Although there were no differences in the size of the synaptic contacts, the total number of synaptic contacts was significantly larger in the transgenic mice, suggesting that the transgenic effect at this age is synaptotrophic and that the presence of amyloid plaques and an elevated Abeta42/40 ratio are not necessarily detrimental to populations of synapses.
The transgenic effect is likely to be developmental, similarly to the remodelling effect recently detected in αMUPA developing incisor teeth [ 226].
DEGs were defined as the probes for which the βi were significantly different from 0, since βi is the estimate for the group (wild-type or transgenic) effect.
To exclude potential influence from transgenic effect, total soluble protein samples from leaves and seeds of transgenic tobacco carrying empty pBI121 plasmid (denoted as EP) were used as negative controls while commercial hG-CSF produced by E.coli was used as positive control.
No correlation was observed for the other transgenic events suggesting a strong transgenic event or genotype effect.
For instance, in the case of a first tier assessment for transgenic plant effects on non-target arthropods, an RQ < 0.1 would be considered evidence of no likely harm [ 35].
Does the deviation in gene expression between the two sets of tumors result from an early transgenic STAT5 effect, or does continuously deregulated STAT5 expression in the tumors govern the gene-expression profile?
We show that rapalog-inducible STAT1 expression can be achieved in vivo, although STAT1 induction is impaired by transgene silencing effects in transgenic mice harbouring randomly integrated gene constructs.
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