Sentence examples for transgenic disruption from inspiring English sources
In this study we have backcrossed a transgenic disruption of the col9a1 gene, which leads to an absence of CIX, into two different inbred mouse strains, DBA/1 and B10.Q.
Previously we have shown that ecdysone signaling at the end of larval growth is the developmental cue for the vCrz PCD, as genetic and transgenic disruption of ecdysone receptor (EcR) B1 and B2 isoforms blocks the PCD (Choi et al., 2006).
To address this hypothesis we investigated the balance of 7KC and 7βOHC in mice with transgenic disruption of 11βHSD1 and H6PDH, and abilities of these 7-oxysterols to influence the equilibrium between the dehydrogenase and reductase activities of glucocorticoid metabolism by murine 11βHSD1.
To understand the importance of CIX for cartilage integrity and stability and in the disease process of arthritis, we used a transgenic disruption of the col9a1 gene, leading to an absence of CIX, in two different genetic backgrounds (DBA/1 and B10.Q).
Due to several advantages, we used HLA-DR3 transgenic mice with targeted disruption of IFN-γ gene for these studies.
These results indicate that the severe T cell deficiency unique to homozygous tgε26 mice is not due to gene disruption by transgenic integration.
These results suggest that the severe immunodeficiency seen in tgε26 mice is not due to gene disruption resulting from transgenic integration.
Complete loss of T cells is observed in homozygous tgε26 mice, but not in heterozygotes, suggesting that genomic disruption due to transgenic integration may contribute to the arrest of T cell development.
Transgenic mice heterozygotes for targeted disruption of the IGF-IR gene have been kindly provided by Dr. Efstradiadis, Columbia University, NY.
These results extend our earlier observations that complete ASIC1a disruption impaired and transgenic ASIC1a overexpression enhanced fear conditioning (Wemmie et al. 2003, 2004).
In this context, our results indicate that oligodendroglial αSYN overexpression in (PLP -αSYN transgenic mice might result in disruPLP -αSYNtransgenic functional neurobiology of the analogue of Onuf's nucleus.
